Temporal profiles of stress protein inductions after focal transient ischemia in mice brain

Q Li, Y Nakano, J Shang, Y Ohta, K Sato… - Journal of Stroke and …, 2016 - Elsevier
HSP70 is neuroprotective by ameliorating postischemic inflammation. Furthermore, HSP70
gene … We also detected a higher expression level of ubiquitin-positive cells in the peri-…

Heat shock protein 70 (HSP70) induction: chaperonotherapy for neuroprotection after brain injury

JY Kim, S Barua, MY Huang, J Park, MA Yenari, JE Lee - Cells, 2020 - mdpi.com
HSP70 neuroprotection in brain injury (ischemic stroke and traumatic brain injury (TBI)), along
with pharmacological HSP70 … CHIP, an ubiquitin ligase, interacts with HSP70 by rounding …

Heat shock protein signaling in brain ischemia and injury

JY Kim, JW Kim, MA Yenari - Neuroscience letters, 2020 - Elsevier
… neuroprotective effects of HSP70 in stroke and brain trauma models. … brain undergoes a
stress response after cerebral ischemia (… CHIP is a ubiquitin ligase that interacts with HSP70 and …

Profiling of signaling proteins in penumbra after focal photothrombotic infarct in the rat brain cortex

S Demyanenko, A Uzdensky - Molecular neurobiology, 2017 - Springer
Hsp70 and Hsp90 decreased by −50 %, −80 %, and −2.8-fold, respectively. Up-regulation
of ubiquitin-like … Ca 2+ also controls gene expression indirectly through the Ca 2+ -dependent …

Protein modifications with ubiquitin as response to cerebral ischemia-reperfusion injury

K Hochrainer - Translational stroke research, 2018 - Springer
… Likewise, after focal ischemia, we detected with lysine specific antibodies … of ubiquitin gene
expression leading to greater availability of … , an Hsp70 inducer, prior to OGD blocks ubiquitin

[HTML][HTML] Global gene expression profile of cerebral ischemia-reperfusion injury in rat MCAO model

C Wang, M Liu, Y Pan, B Bai, J Chen - Oncotarget, 2017 - ncbi.nlm.nih.gov
gene expression in the hippocampi of Wistar rats following … Wfs1 negatively regulates Atf6α
through the ubiquitin-… of our lab [10, 42], rats were subjected to focal ischemia for 2 h, and the …

The 70-kDa heat shock protein (Hsp70) as a therapeutic target for stroke

JY Kim, Y Han, JE Lee, MA Yenari - Expert opinion on therapeutic …, 2018 - Taylor & Francis
… to the N-terminus of Hsp70, and the E3-ubiquitin ligase CHIP (C-terminus of … Hsp70
overexpression and tolerance in ischemic stroke. Following 10 min of focal cerebral ischemia, Hsp70

Regulation of mRNA following brain ischemia and reperfusion

DJ DeGracia - Wiley Interdisciplinary Reviews: RNA, 2017 - Wiley Online Library
… SGs colocalized with punctate ubiquitinated structures at late … link between HuR and HSP70
translation following brain I/R. … mediated interactions alter gene expression patterns such as …

Neuroprotective effects of heat shock protein70

F Mohammadi, N Nezafat… - CNS & Neurological …, 2018 - ingentaconnect.com
… of HSP70, and N-terminal of Bag-1 binds to the E3-ubiquitin … to apoptosis intensification after
a focal cerebral ischemia [61]. … on expression of the HSP70 after brain ischemia/reperfusion. …

Role of a heat shock transcription factor and the major heat shock protein Hsp70 in memory formation and neuroprotection

OG Zatsepina, MB Evgen'ev, DG Garbuz - Cells, 2021 - mdpi.com
… In cerebral ischemia in rats, neurons expressing Hsp70 have … latter with the participation of
the ubiquitin ligase CHIP, which … In this study, the Hsp70 level begins to increase shortly after